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C16 (drug)
C16 or PKRi is a drug which acts as a selective inhibitor of the enzyme double-stranded RNA-dependent protein kinase (PKR). It has been shown to effectively inhibit PKR function ''in vivo'' and has neuroprotective and nootropic effects in animal studies.〔Jammi NV, Whitby LR, Beal PA. Small molecule inhibitors of the RNA-dependent protein kinase. ''Biochemical and Biophysical Research Communications''. 2003 Aug 15;308(1):50-7. PMID 12890478〕〔Shimazawa M, Hara H. Inhibitor of double stranded RNA-dependent protein kinase protects against cell damage induced by ER stress. ''Neuroscience Letters''. 2006 Dec 6;409(3):192-5. PMID 17055645〕〔Couturier J, Morel M, Pontcharraud R, Gontier V, Fauconneau B, Paccalin M, Page G. Interaction of double-stranded RNA-dependent protein kinase (PKR) with the death receptor signaling pathway in amyloid beta (Abeta)-treated cells and in APPSLPS1 knock-in mice. ''Journal of Biological Chemistry''. 2010 Jan 8;285(2):1272-82. PMID 19889624〕
==See also==
* S-17092
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